A true endocrine disorder can slow weight reduction, alter appetite, increase fluid retention, and worsen body composition, but the phrase hormonal imbalance is too vague to explain a plateau by itself.
Insulin resistance can increase hunger, liver fat, glucose variability, and cardiometabolic risk while fasting glucose remains normal. It can make weight control harder, but it does not make a calorie deficit physiologically impossible.
Common variants near FTO can increase obesity susceptibility, often through appetite and satiety pathways, but they are not a genetic sentence and do not explain an individual’s entire weight history.
You cannot erase inherited sequence through willpower, but you can change the pathway from genetic susceptibility to obesity through environmental design, appetite treatment, exercise, medication, and surgery.
Parents transmit genes, appetite traits, household environments, early-life exposures, cultural routines, and socioeconomic constraints. Childhood obesity is inherited through a system, not one route.